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Biosciences Publications, Presentations, Abstracts, and Patents

2010

Jump to: Cancer Biology | Drug Discovery | Immunology and Inflammation | Infectious Disease and Biodefense| Neuroscience | Pharmaceutical Sciences | Preclinical Development | Radiation Biology and Therapy | Safety Toxicology, Drug Metabolism, and Pharmacokinetics | Patents

Cancer Biology

Publications

Duellman SJ, Calaoagan JM, Sato BG, Fine R, Klebansky B, Chao WR, Hobbs, P, Collins N. Sambucetti L, Laderoute KR. A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha). Biochem Pharmacol. 2010;80(6):819-826.

Jang T, Calaoagan JM, Kwon E, Samuelsson S, Recht L, Laderoute KR. 5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat. Int J Cancer. 2010. Epub July 15.

Kapetanovic IM, Muzzio M, Hu SC, Crowell JA, Rajewski RA, Haslam JL, Jong L, McCormick DL. Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. Cancer Chemother Pharmacol. 2010;65(6):1109-1116.

Laderoute KR, Calaoagan JM, Madrid PB, Klon AE, Ehrlich PJ. SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK). Cancer Biol Ther. 2010;10(1):68-76.

Machrouhi F, Ouhamou N, Laderoute K, Calaoagan J, Bukhtiyarova M, Ehrlich PJ, Klon AE. The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity. Bioorg Med Chem Lett. 2010;20(22):6394-6399.

Rausch L, Green C, Steinmetz K, Levalley S, Catz P, Zaveri N, Schweikart K, Tomaszewski J, Mirsalis J. Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator. Cancer  Chemother Pharmacol. 2010. Epub August 25.

Shi Y, Amin K, Sato BG, Samuelsson SJ, Sambucetti L, Haroon ZA, Laderoute K, Murphy BJ. The metal-responsive transcription factor-1 protein is elevated in human tumors. Cancer Biol Ther. 2010;9(6):469-476.

Waleh NS, Murphy BJ, Zaveri NT. Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179. Cancer Lett. 2010;289(1):111‑118.

Waleh NS, Murphy BJ, Zaveri NT. Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179. Cancer Lett. 2010;289(1):111‑118.

Wang J, Krishnamoorthi V, Wang E, Yang C, Baptista D, Wu X, Liu M, Gardner M, Elkins P, Hines J, Liu P. LC/MS characterization of impurities and degradation products of a potent antitumor peptidic dimer, CU201. J Pharm Biomedl Anal. 2010;51(4):824-833.

Abstracts and Presentations

Chao W-R, Shi Y, Dinh D, Hou C, Sambucetti L. Antitumor activity of SR16388 against human multiple myeloma in vitro and in vivo. Presented at: AACR 101st Annual Meeting; Session: Experimental and Molecular Therapeutics, Poster Section 23.
Abstract No. 1569. American Association for Cancer Research. April 17-21, 2010: Washington, D.C.

Jong L, Chao W-R, Shi Y, Green C, Sambucetti L, Collins N. Novel anticancer agents modulate multiple signal transduction pathways for cancer therapy. Presented at:  AACR 101st Annual Meeting. American Association for Cancer Research. April 17-21, 2010: Washington, D.C.

Machrouhi F, Klon A, Ouhamou N, Laderoute K, Calaoagan J, Bukhtiyarova M,
Ehrlich P. Fragment based drug design approach for the identification and optimization of potent inhibitors of 5'-AMP-activated protein kinase, AMPK. Poster No. 477. Presented at:  239th ACS National Meeting. March 21-25, 2010, American Chemical Society: San Francisco.

Rotunno M, Hu N, Wang C, Goldstein AM, Bergen AW, Consonni D, Pesatori AC, Bertazzi PA, Wacholder S, Shih J, Caporaso NE, Taylor PR, Landi MT. A candidate gene expression signature of early stage lung adenocarcinoma from peripheral whole blood. Presented at: AACR 101st Annual Meeting. American Association for Cancer Research. April 17-21, 2010: Washington, D.C.

Wang D. Targeting Immunogenic Sugar Moieties of HIV-1 and Human Cancers. Presented at: NIH/NCI Workshop, Integrating Glycomics with Other Omics in Cancer Detection and Diagnosis, January 19, 2010, Menlo Park, CA.

Wang D. Probing Immunogenic Sugar Moieties of HIV-1 using Carbohydrate
Cluster Microarray. Presented at: NIH/ NIGMS Workshop, Glycan Microarrays, September 19-21, 2010: Emory University, Atlanta, GA.

Zamani SA, Roy A, Zhai L, Li R, Qu Z. Serotonin signal transduction in human endothelial cells. Abstract No. 2390. Presented at: AACR 101st Annual Meeting. American Association for Cancer Research. April 17-21, 2010: Washington, D.C.

Zhang J, Arzberger S, Knowlton N, Wang D. ADA’s 3-D Glycan Cluster Microarray:
a New Tool for Glycomics Research. Presented at: NIH/NIGMS Workshop, Glycan Microarrays, September 19-21, 2010: Emory University, Atlanta, GA.

Drug Discovery and Medicinal Chemistry

Publications

Klock C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett. 2010. Epub December 16.

Kozocas JA, Bupp JE, Tanga MJ, Pluhar JT, Wainer IW. Synthesis of Tritium Labeled (R,R)-4-Methoxyfenoterol. J Labelled Comp Radiopharm. 2010;53(2):68-72.

Machrouhi F, Ouhamou N, Laderoute K, Calaoagan J, Bukhtiyarova M, Ehrlich PJ, Klon AE. The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity. Bioorg Med Chem Lett. 2010;20(22):6394-6399.

Malerich JP, Lam JS, Hart B, Fine RM, Klebansky B, Tanga MJ, D’Andrea A. Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3. Bioorg Med Chem Lett. 2010;20(24):7454-7457.

Moaddel R, Venkata SL, Tanga MJ, Bupp JE, Green CE, Iyer L, Furimsky A, Goldberg ME, Torjman MC, Wainer IW. A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. Talanta 2010;82(5):1892-1904.

Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. J Med Chem. 2010;53(9):3685-3695.

Song B, Kibler P, Malde A, Kodukula K, Galande AK. Design of short linear peptides that show hydrogen bonding constraints in water. J Am Chem Soc. 2010;132(13):4508-4509.

Wang J, Krishnamoorthi V, Wang E, Yang C, Baptista D, Wu X, Liu M, Gardner M, Elkins P, Hines J, Liu P. LC/MS characterization of impurities and degradation products of a potent antitumor peptidic dimer, CU201. J Pharm Biomedl Anal. 2010;51(4):824-833.

Zhou W, Madrid P, Fluitt A, Stahl A, Xie XS. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.
J Biomol Screen. 2010;15(5):488-497.

Zaveri N, Jiang F, Olsen C, Polgar W, Toll L. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem. 2010;53(22):8187-8191.

Abstracts and Presentations

Beaulieu ED, Gollob KJ, Dutra WO, Olson LL, Tanga MJ. Progress towards the development of a fluorimetric diagnostic for the early detection of trypanosomatid diseases. Presented at: 39th ACS National Meeting. American Chemical Society,
March 21-25, 2010: San Francisco.

Chopra S, Tran T, Matsuyama K, Hokama L, Collins CJ, Ryan KJ, Fuchs-Knotts T,
Iyer LV, Tanga M, Madrid P, Mortelmans K. Synthesis and Microbiological Evaluation of Novel Nitrofuran Compounds Against Methicillin-resistant Staphylococcus aureus, Presented at: 2010 Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), American Society for Microbiology. September 12-15, 2010: Boston.

Rhee S-W. Radioactive Isotope Labeling Program at SRI. Presented at: Korea Atomic Energy Research Institute. February 2, 2010: Daejeon, Korea.

Steinmetz, K. In Vitro Toxicity Testing: What, Why & How, Presented at: 4th Drug Discovery for Neurodegeneration Conference, Section II. In-vitro Testing: Early Phases of Drug Discovery, February 1, 2010: Houston.

Immunology and Inflammation

Publications

Lima PM, Souza PE, Costa JE, Gomez RS, Gollob KJ, Dutra WO. Aggressive and chronic periodontitis correlate with distinct cellular sources of key immunoregulatory cytokines. J Periodontol. 2010;82(1):86-95. Epub September 1.

Malerich JP, Lam JS, Hart B, Fine RM, Klebansky B, Tanga MJ, D’Andrea A. Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3. Bioorg Med Chem Lett. 2010;20(24):7454-7457.

Torres KC, Dutra WO, de Rezende VB, Cardoso F, Gollob KJ, Teixeira AL. Monocyte dysfunction in Sydenham’s chorea patients. Hum Immunol. 2010;71(4):351-354.

Villani FN, Rocha MO, Nunes Mdo C, Antonelli LR, Magalháes LM, dos Santos JS, Gollub KJ, Dutra WO. Trypanosoma cruzi-induced activation of functionally distinct αβ and γδ CD4- CD8- T cells in individuals with polar forms of Chagas’ disease. Infect Immun. 2010;78(10):4421-4430.

Abstracts and Presentations

Alt C, Harrison T, Zukic M, Mirsalis J, D’Andrea A. Cytokine measurements in a mouse vaginal irritation model for the safety evaluation of microbicides. Presented at: 16th International Conference. Inflammation Research Association, September 26-29, 2010: Chantilly, VA.

Gollub K. Immunoregulatory networks in human leishmaniasis: perspective for novel therapies. Presented at UC Berkeley’s weekly seminar series in the Division of Infectious Diseases at the School of Public Health. April 5, 2010: Berkeley, CA.

Infectious Disease and Biodefense

Publications

Chopra S, Torres-Ortiz M, Hokama L, Madrid P, Tanga M, Mortelmans K, Kodukula K, Galande AK. Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii. J Antimicrob Chemother. 2010;65(12):2598-2601.

Coelho dos Santos JS, Menezes CA, Villani FN, Magalhaes LM, Scharfstein J, Gollob KJ, Dutra WO. Captopril increases the intensity of monocyte infection by Trypanosoma cruzi and induces human T helper type 17 cells. Clin Exp Immunol. 2010;162(3):528-536.

Flores-Valdez MA, Chopra S. Global reemergence of tuberculosis: are host defense peptides an option to ameliorate disease burden? Microb Drug Resist. 2010:1‑7.

Gates SD, Daniel McCartt A, Lappas P, Jeffries JB, Hanson RK, Hokama LA, Mortelmans K. Bacillus endospore resistance to gas dynamic heating. J Appl Microbiol. 2010;109(5):1591-1598.

Held DM, Shurtleff AC, Fields S, Green C, Fong J, Jones RG, Sesardic D, Buelow R, Burke RL. Vaccination of rabbits with an alkylated toxoid rapidly elicits potent neutralizing antibodies against botulinum neurotoxin serotype B. Clin Vaccine Immunol. 2010;17(6):930-936.

Lima PM, Souza PE, Costa JE, Gomez RS, Gollob KJ, Dutra WO. Aggressive and chronic periodontitis correlate with distinct cellular sources of key immunoregulatory cytokines. J Periodontol. 2010;82(1):86-95. Epub September 1.

Torres KC, Dutra WO, de Rezende VB, Cardoso F, Gollob KJ, Teixeira AL. Monocyte dysfunction in Sydenham’s chorea patients. Hum Immunol. 2010;71(4):351-354.

Villani FN, Rocha MO, Nunes Mdo C, Antonelli LR, Magalháes LM, dos Santos JS, Gollub KJ, Dutra WO. Trypanosoma cruzi-induced activation of functionally distinct αβ and γδ CD4- CD8- T cells in individuals with polar forms of Chagas’ disease. Infect Immun. 2010;78(10):4421-4430.

Abstracts and Presentations

Beaulieu ED, Gollob KJ, Dutra WO, Olson LL, Tanga MJ. Progress towards the development of a fluorimetric diagnostic for the early detection of trypanosomatid diseases. Presented at: 39th ACS National Meeting. American Chemical Society,
March 21-25, 2010: San Francisco.

Burke RL, Gilfillan L, Glaser B, Keepers T, Manger ID, Madrid PM, Samuelsson S, Tanga MJ. Chloroquine is a potent inhibitor of Ebola virus in vitro and in vivo. Presented at:  2010 Chemical and Biological Defense Science and Technology Conference. Defense Threat Reduction Agency (DTRA), November 15-19, 2010: Orlando, FL.

Chopra S, Tran T, Matsuyama K, Hokama L, Collins CJ, Ryan KJ, Fuchs-Knotts T,
Iyer LV, Tanga M, Madrid P, Mortelmans K. Synthesis and Microbiological Evaluation of Novel Nitrofuran Compounds Against Methicillin-resistant Staphylococcus aureus, Presented at: 2010 Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), American Society for Microbiology. September 12-15, 2010: Boston.

Gollub K. Immunoregulatory networks in human leishmaniasis: perspective for novel therapies. Presented at UC Berkeley’s weekly seminar series in the Division of Infectious Diseases at the School of Public Health. April 5, 2010: Berkeley, CA.

Vaidyanathan R. ATP Synthesis and Mosquito Vector Competence for Arboviruses. Presented at: Jugatae Seminar, the Rogoff Lecture in Entomolgy. September 27, 2010: Cornell University, Ithaca, NY.

Watson DS, Feng X, Askew DS, Jambunathan K, Kodukula K, Galande AK. Secreted proteases of Aspergillus fumigatus as targets for diagnosis of invasive aspergillosis. Presented at:  Pathways to improving diagnosis of invasive aspergillosis: The 2010 Combined IAAM and AsTeC Workshop. November 15, 2010. Bethesda, MD.

Watson DS, Najvar L, Feng X, Kirkpatrick W, Wiederhold N, Patterson T, Kodukula K, Askew D, Galande A. Secreted proteases of Aspergillus fumigatus as targets for diagnosis of invasive aspergillosis. Presented at: 50th Annual ICAAC. American Society for Microbiology. September 14, 2010. Boston.

Neuroscience

Publications

Jozwiak K, Toll L, Jimenez L, Woo AYH, Xiao RP, Wainer IW. The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the β₂-adrenoceptor. Biochem Pharmacol. 2010;79(11).1610-1615.

Jozwiak K, Woo AYH, Tanga MJ, Toll L, Jimenez L, Kozocas JA, Plazinska A, Xiao RP, Wainer IW. Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective β₂-adrenergic receptor agonists. Bioorg Med Chem. 2010;18(2):728-736.

Khroyan TV, Polgar WE, Cami-Kobeci G, Husbands SM, Zaveri NT, Toll L. The First ‘Universal Opioid Ligand’ (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy -6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-induced Reward. J Pharmacol Exp Ther. 2010. Epub December 21.

Kilduff TS, Cauli B, Gerashchenko D. Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation? Trends Neurosci. 2010. Epub October 26.

Pasumarthi RK, Fadel J. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. J Neurochem. 2010;113(4):1023-1035.

Pasumarthi RK, Gerashchenko D, Kilduff TS. Further characterization of sleep-active neuronal nitric oxide synthase neurons in the mouse brain. Neuroscience. 2010;169(1): 149-157.

Teegarden BR, Li H, Jayakumar H, Strah-Pleynet S, Dosa PI, Selaya SD, Kato N, Elwell KH, Davidson J, Cheng K, Saldana H, Frazer JM, Whelan K, Foster J, Espitia S, Webb RR, Beeley NRA, Thomsen W, Morairty SR, Kilduff TS, Al-Shamma HA. Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2, 4-difluorophenyl) urea (Nelotanserin) and Related 5-Hydroxytryptamine_2A Inverse Agonists for the Treatment of Insomnia. J Med Chem. 2010;53(5):1923-1936.

Thompson CL, Wisor JP, Lee CK, Pathak SD, Gerashchenko D, Smith KA, Fischer SR, Kuan CL, Sunkin SM, Ng LL, Lau C, Hawrylycz M, Jones AR, Kilduff TS, Lein ES. Molecular and anatomical signatures of sleep deprivation in the mouse brain. Front Neurosci. 2010;4:165.

Toll L, Jimenez L, Waleh N, Jozwiak K, Woo AY, Xiao RP, Bernier M, Wainer IW. β2‑Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells. J Pharmacol Exp Ther. 2010;336(2):524-532. Epub November 11.

Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. Pediatr Res. 2010;68(4):292-297.

Wallace TL, Callahan PM, Tehim A, Bertrand D, Tombaugh G, Wang S, Xie W, Rowe WB, Ong V, Graham E, Terry AV Jr, Rodefer JS, Herbert B, Murray M, Porter R, Santarelli L, Lowe DA. RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents. J Pharmacol Exper Ther 2010. Epub October 19.

Zaveri N, Jiang F, Olsen C, Polgar W, Toll L. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem. 2010;53(22):8187-8191.

Abstracts and Presentations

Greco MA, Murrary J, Talcott C. Modeling Sleep-related Activities from Experimental Observations − Initial computational frameworks for understanding sleep function(s), Presented at:  3rd International Conference on Applied Human Factors and Ergonomics (AHFE), Session 27:  Informing Computational Neuroergonomics. July 17-20, 2010: Miami, FL.

Khroyan TV, Polgar W, Jiang F, Stauber G, Zaveri N, Toll L. A highly selective α3 β4 nicotinic receptor antagonist attenuates cocaine and morphine-induced place preference. Poster No. 236.12. Presented at:  Society for Neuroscience 40^th Annual Meeting. November 13-17, 2010: San Diego.

Orduna J, Waleh N, Bell RL, Montenegro J, Zaveri N, Toll LR.l, Effect of alcohol on spinal nerve ligation-induced neuropathy in alcohol preferring rats. Presented at: Society for Neuroscience 40^th Annual Meeting Poster Session 375. Pain Models: Behavior. Poster No. 375.22. November 14-15, 2010: San Diego.

Steinmetz, K. In Vitro Toxicity Testing: What, Why & How, Presented at: 4th Drug Discovery for Neurodegeneration Conference, Section II. In-vitro Testing: Early Phases of Drug Discovery, February 1, 2010: Houston.

Toll LR, Waleh N, Jimenez L, Polgar W, Orduna J, Green C, Gow J, O’Loughlin K, Bernier M, Wainer IW. Selective β2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells in vitro and in vivo. Presented at: Society for Neuroscience 40^th Annual Meeting. Poster Session 262. Neuro-Oncology. Poster No. 262.25. November 14-15, 2010: San Diego.

Vazquez J, Polgar W, Toll LR. Nociceptin (N/OFQ) effects on cocaine-induced dopamine (DA) release in nucleus accumbens (NAcc) of rat. Presented at: Society for Neuroscience 40^th Annual Meeting. Poster Session 368. Neural Mechanisms of Drug Addiction. Poster No. 368.21. November 14-15, 2010: San Diego.

Wallace TL, Chiu G, Dao H, Santarelli L, Porter R, Bertrand S, Bertrand D. Modulation of Cholinergic Tone Impacts the Efficacy of RG3487 / MEM3454, A Novel, Nicotinic Alpha 7 Receptor Agonist. Presented at: Society for Neuroscience 40^th Annual Meeting. Poster Session 236. Nicotinic Acetylcholine Receptors: Potential Therapeutic Applications. Poster No. 236.1. November 13-17, 2010: San Diego.

Wurts Black S, Morairty S, Iacopetti C, Silveira K, Valladao D, Kilduff TS. Gammahydroxybutyrate and R-baclofen promote NREM sleep in hypocretin/ataxin-3 mice. Sleep, 33 (Abstract Supplement): A4. Presented at SLEEP 2010, June 5-9, 2010: San Antonio, TX.

Xie XS, Zou B, Xie J, Gerashenko D, Khroyan T, Wurts Black S, Toll L, Zaveri N, Sakurai T, Pasumarthi RK. Nociceptin/orphanin FQ receptor-mediated anxiolytic effects through interaction with hypocretin/orexin neurons in mice. Sleep, 33 (Abstract Supplement): A76. Presented at SLEEP 2010, June 5-9, 2010: San Antonio, TX.

Pharmaceutical Sciences

Publications

Shankar G. The Right Formulation − and how to get there. ONdrugDelivery; Oral Drug Delivery & Advanced Excipients issue. Frederick Furness Publishing, April 2010:21-24.

Abstracts and Presentations

Bejugam NK, Mutyam SK, Aroian RV, Shankar GN. Gastroresistant Microencapsulated Crystal (Cry5B) Protein Formulations for Next-Generation Anthelmintics. Presented at: AAPS 2010 Meeting Annual Meeting. Poster Session:  Drug Delivery Biopharmaceutics. Poster No. T2042. American Association of Pharmaceutical Scientists, November 14-18, 2010: New Orleans.

Mutyam SK, Bejugam NK, Struble E, Parish HJ, Reddy VM, Bogatcheva E, Shankar GN. Preclinical Formulation Development of Antimycobacterial Drug SQ641. Presented at: AAPS 2010 Annual Meeting. Poster Session:  Drug Delivery - Pharmaceutical Technologies (Small Molecule). Poster No. W5105. American Association of Pharmaceutical Scientists November 14-18, 2010: New Orleans.

Shankar GN, Weber W, Doyle-Eisele M, Bejugam N, Mutyam S, Guilmette RA. Oral
Ca‑ and Zn-DTPA: A Novel Tablet Formulation with Improved Decorporation of Americium-241, Presented at: Radiation Research Society 56th Annual Meeting. September 26-29. 2010: Maui.

Preclinical Development

Publications

Moos W. Nonprofits and the Valley of Death in Drug Discovery. Xconomy. San Francisco ed. 2010. Epub August 19.

Abstracts and Presentations

Moos W. A Drug Hunter’s Potpourri. Presented at: Medicinal Chemistry & Biochemistry Department. James Madison University, March 3, 2010: Harrisonburg, VA.

Moos W. Pharmaceutical Math – Infectious Disease by the Numbers. Presented at: Department of Integrated Science and Technology, James Madison University,
March 2, 2010: Harrisonburg, VA.

Moos W. SRI Biosciences – Your Partner from Idea to IND^™. Presented at: Department of Integrated Science and Technology, James Madison University, March 3, 2010: Harrisonburg, VA.

Moos W. The Urgency of Pharmaceutical Innovation: Saving Lives Through Drug Discovery. Presented at: Baker Forum, Cal Poly President’s Cabinet, Cal Poly,
May 2, 2010: San Luis Obispo, CA.

Radiation Biology and Therapy

Publications

Abergel RJ, Durbin PW, Kullgren B, Ebbe SN, Xu J, Chang PY, Bunin DI, Blakely EA, Bjornstad KA, Rosen CJ, Shuh DK, Raymond KN. Biomimetic Actinide Chelators: An Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Health Phys. 2010; 99(3):401-407.

Blakely EA, Kleiman NJ, Neriishi K, Chodick G, Chylack LT, Cucinotta FA, Minamoto, A, Nakashima E, Kumagami T, Kitaoka T., Kanamoto T, Kiuchi Y, Chang P, Fujii N, Shore,RE. Radiation cataractogenesis: epidemiology and biology. Radiat Res. 2010;173(5):709-717.

Chang PY, Doppalapudi R, Bakke J, Wang A, Menda S, Davis Z. Biological impact of low dose-rate simulated solar particle event radiation in vivo. Radiat Environ Biophys. 2010;49(3):379-388.

Huang YY, Ma KH, Tseng TW, Chou TK, Ng H, Mirsalis JC, Fu YK, Chu TC, Huang WS, Shiue,CY. Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[¹⁸F]-ADAM in rats and monkeys. Eur J Nucl Med Mol Imaging. 2010;37(3):545-555.

Moaddel R, Venkata SL, Tanga MJ, Bupp JE, Green CE, Iyer L, Furimsky A, Goldberg ME, Torjman MC, Wainer IW. A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. Talanta 2010;82(5):1892-1904.

Abstracts and Presentations

Rhee S-W. Radioactive Isotope Labeling Program at SRI. Presented at: Korea Atomic Energy Research Institute. February 2, 2010: Daejeon, Korea.

Safety Toxicology, Drug Metabolism, and Pharmacokinetics

Publications

Coughlin JE, Padmanabhan S, Zhang G, Kirk CJ, Govardhan CP, Korba BE, O’Loughlin K, Green CE, Mirsalis J, Morrey JD, Iyer RP. Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs. Bioorg Med Chem Lett. 2010;20(5):1783-1786.

Green CE, Swezey R, Bakke J, Shinn W, Furimsky A, Bejugam N, Shankar GN, Jong L, Kapetanovic IM. Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent. Cancer Chemother Pharmacol. 2010. Epub July 10.

Rausch L, Green C, Steinmetz K, Levalley S, Catz P, Zaveri N, Schweikart K, Tomaszewski J, Mirsalis J. Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator. Cancer  Chemother Pharmacol. 2010. Epub August 25.

Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. J Med Chem. 2010;53(9):3685-3695.

Siluk D, Mager DE, Kim HS, Wang Y, Furimsky AM, Ta A, Iyer LV, Green CE, Wainer IW. Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat. Xenobiotica. 2010;40(3):195-206.

Abstracts and Presentations

Steinmetz, K. In Vitro Toxicity Testing: What, Why & How, Presented at: 4th Drug Discovery for Neurodegeneration Conference, Section II. In-vitro Testing: Early Phases of Drug Discovery, February 1, 2010: Houston.

Patents

Jong L and Chao W-R. Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents. US Patent No. 7,666,897. Issued February 23, 2010.

Peters RH, Liu J-W, Johansson JG, Ryan KJ, Chao W-R, Tanabe M. Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one. US Patent No. 7,772,218. Issued August 10, 2010

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       Last Updated May 18, 2011