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Biosciences Publications, Presentations, Abstracts, and Patents

  2008

Jump to: Cancer Biology | Drug Discovery and Medicinal Chemistry| Infectious Disease and Biodefense| Neurobiology | Preclinical Development and Pharmaceutical Sciences |Radiation Biology and Therapy | Other|

Cancer Biology

Publications

Clement, G., I. Guilleret, B. He, A. Yaqui-Beltran, Y.C. Lin, L. You, Z. Xu, Y. Shi, J. Okamoto, J. Benhattar, and D. Jablons. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett’s esophagus. Cancer Sci 99:46–53, 2008.

Mishra, R., B.L. Cool, K.R. Laderoute, M. Foretz, B. Viollet, and M.S. Simonson. AMP-activated protein kinase inhibits transforming growth factor-alpha-induced Smad3-dependent transcription and myofibroblast transdifferentiation. J Biol Chem 283(16):10461-10469, 2008.

Murphy, B.J., T. Kimura, B.G. Sato, Y. Shi, and G.K. Andrews. Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1{alpha}. Mol Cancer Res 6(3):483–90, 2008.

Papandreou, I., A.L. Lim, K. Laderoute, and N.C. Denko. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death and Diff 15(10:1572–1581, 2008.

Abstracts and Presentations

Pan, C.P., Y. Shi, K. Amin, J.P. Haushalter, C.S. Greenberg, Z. Haroon, and G.W. Faris. Near infrared fluorescent imaging of tumor boundaries using tissue transglutaminase substrate. Biomedical Optics (BIOMED), Optical Society of America (OSA) Topical Meeting, St. Petersburg, FL, March 2008.

Pan, C.P., Y. Shi, K. Amin, J.P. Haushalter, C.S. Greenberg, Z. Haroon, and G.W. Faris. Near-infrared fluorescent labeling of tissue transglutaminase substrates for imaging tumor boundaries. Conference on Lasers and Electro-Optics (CLEO), San Jose, CA, May 2008.

Pan, C.P., Y. Shi, K. Amin, J.P. Haushalter, C.S. Greenberg, Z. Haroon, and G.W. Faris. Near-infrared fluorophore-labeled tissue transglutaminase substrates for imaging tumor boundaries. Era of Hope, Baltimore, MD, June 2008.

Drug Discovery and Medicinal Chemistry

Publications

Chrisman, W., M.G. Knize, and M.J. Tanga. Synthesis and mutagenic potency of structural isomers of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. J Heterocyclic Chem 45:1641–1649, 2008.

Dawson, M. I., Z. Xia, T. Jiang, M. Ye, J.A. Fontana, L. Farhana, B. Patel, P.X. Li, M. Bhuiyan, R. Pellicciari, A. Macchiarulo, R. Nuti, X.K. Zhang, Y.H. Han, L. Tautz, P.D. Hobbs, L. Jong, N. Waleh, W.R. Chao, G.S. Feng, Y. Pang, and Y. Su. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: Effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of Src homology 2 domain-containing protein tyrosine phosphatase-2 activity. J Med Chem 51(18):5650–5662, 2008.

Ding, D., Y. Shi, G. Shaltiel, A.N. Azab, E. Pullumbi, A. Campbell, D.V. Mehta, G. Agam, and M.L. Greenberg. Yeast bioassay for identification of inositol depleting compounds. World J Biol Psychiatry:1–7, October 31, 2008 (Epub ahead of print).

Ghirmai, S., M.R. Azar, W.E. Polgar, I. Berzetei-Gurske, and J.R. Cashman. Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14 beta-dihydroxy-4, 5 alpha-epoxymorphinan: Potential alcohol-cessation agents. J Med Chem 51(6):1913-1924, 2008.

Morairty, S., L. Hedley, J. Flores, R. Martin, and T.S. Kilduff. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep 31:34–44, 2008.

Pei, Y., W.H. Moos, and S. Ghosh. Rapid lead identification of inhibitors of adenine nucleotide translocase: A case study of applying combinatorial chemistry techniques in drug discovery. In High-Throughput Lead Optimization in Drug Discovery, T. Kshirsagar, Ed., pp. 165–176. CRC Press, Boca Raton, FL, 2008.

Spagnolo, B., G. Calo, W.E. Polgar, F. Jiang, C.M. Olsen, I. Berzetei-Gurske, T.V. Khroyan, S.M. Husbands, J.W. Lewis, L. Toll, and N.T. Zaveri. Activities of mixed NOP/opioid receptor ligands. British J Pharmacol 153:609–619, 2008.

Tanga, M.J., J.A. Kozocas, and T.K. Tochimoto. Synthesis of two potential heterocyclic amine food mutagens. J Heterocyclic Chem 45:661–665, 2008.

Abstracts and Presentations

Sambucetti, L.C., M. Tanabe, W.-R. Chao, N. Zaveri, P. Hobbs, L. Jong, R.H. Peters, B. Sato, C. Olson, M.J. Tanga, H. Jaber Parish, N. Collins, and J. Mirsalis. The role of chemical development in translating novel therapeutic agents into clinical applications; case studies in the development of novel, tissue-selective, estrogen receptor antagonists. AACR 99th Annual Meeting, San Diego, CA, April 12–15, 2008.

Toll, L., I.P. Berzetei-Gurske, I.W. Wainer, K. Jozwiak, L. Jimenez, M.A. Khadeer, M. Bernier, A. Plazinska, M.J. Tanga, and J.A. Kozocas. Binding characteristics and 3-D QSAR of fenoterol stereoisomers and analogs. Society for Neuroscience Annual Meeting, Washington, DC, November 15–18, 2008.

Infectious Disease and Biodefense

Publications

Vaidyanathan, R., A.E. Fleisher, S.L. Minnick, K.A. Simmons, T.W. Scott. Nutritional stress affects mosquito survival and vector competence for West Nile Virus. Vector-Borne and Zoonotic Diseases 8(6):727–732, December 2008.

Abstracts and Presentations

Lappas, P., H.R. Daniel, J.M. Porter, D.F. Davidson, J.B. Jeffries, R.K. Hanson, L.A. Hokama, and K. Mortelmans. Destruction of bacterial-spore-laden aqueous aerosols in stock-heated flows. Optical Society of America, St. Petersburg, FL, March 17–20, 2008.

Matusyama, K., L.A. Hokama, J. Cisneros, A. Bettridge, T. Tran, L. Olson, M. Tanga, and K. Mortelmans. Antimicrobial activity produced by various compounds against virulent biodefense organisms. Society for Industrial Microbiology, San Diego, CA, August 10–14, 2008.

Shurtleff, A., D. Held, J. Fong, T. Keepers, C. Green, J. Shimon, B. Chavez, T. Low, D. Sesardic, R. Jones, J. Barbieri, R. Buelow, and R.L. Burke. Human polyclonal antibodies from transgenic rabbits neutralize botulinum neurotoxin. 45th Annual Interagency Botulism Research Coordinating Committee (IBRCC) Meeting, Philadelphia, PA, September 14–18, 2008.

Neurobiology

Publications

Doran, S.M., T. Wessel, T.S. Kilduff, F. Turek, and J.J. Renger. Translational models of sleep and sleep disorders. In Animal and Translational Models for CNS Drug Discovery, Volume 1: Psychiatric Disorders, R.A. McArthur and F. Borsini, Eds, pp. 395–456. Elsevier, Amsterdam, 2008.

Erickson, R.I., A.A. Paucar, R.L. Jackson, K. Visnyei, and H. Kornblum. Roles of insulin and transferrin in neural progenitor survival and proliferation. J Neurosci Res 86(8):1884–1894, 2008.

Gerashchenko, D., J.P. Wisor, D. Burns, R.K. Reh, P.J. Shiromani, T. Sakurai, H.O. de la Iglesia, and T.S. Kilduff. Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci USA 105:10227–32, 2008.

Greco, M.A., P. Fuller, T.C. Jhou, S. Martin-Schild, J.E. Zadina, Z. Hu, P. Shiromani, and J. Lu. Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus. Brain Res 1245:96–107, December 15, 2008 (Epub ahead of print, September 24, 2008).

Kilduff, T.S., E.S. Lein, H.O. de la Iglesia, T. Sakurai, Y-H. Fu, and P. Shaw. New developments in sleep research: molecular genetics, gene expression, and systems neurobiology. J Neurosci 28:11814–11818, 2008.

Pfefferbaum, A., N.M. Zahr, D. Mayer, S. Vinco, J. Orduna, T. Rohlfing, and E.V. Sullivan. Ventricular expansion in wild-type Wistar rats after alcohol exposure by vapor chamber. Alcoholism: Clin Exp Res 32(8):1459–1467, 2008.

Rawls, S.M., S. Baron, Z. Ding, C. Roth, N. Zaveri, and R.B. Raffa. Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians. Neuropeptides 42(3):229–237, 2008.

Terao, A., Z-L. Huang, J.P. Wisor, T. Mochizuki, D. Gerashchenko, Y. Urade, and T.S. Kilduff. Gene expression in the rat brain during Prostaglandin D2- and adenosinergically-induced sleep. J Neurochem 105:1480–98, 2008.

Vazquez, J., S.C. Hall, H.E. Witkowska, and M.A. Greco. Rapid alterations in cortical protein profiles underlie spontaneous sleep and wake bouts. J Cell Biochem 105:1472–1484, 2008.

Wisor, J.P., R. Pasumarthi, D. Gerashchenko, C. Thompson, S. Pathak, A. Sancar, P. Franken, E.S. Lein, and T.S. Kilduff. Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. J Neurosci 28:7193–201, 2008.

Xie, X., J. Wisor, J. Hara, T. Crowder, R. LeWinter, T.V. Khroyan, A. Yamanaka, S. Diano, T.L. Horvath, T. Sakurai, L. Toll, and T.S. Kilduff. Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. J Clin Invest 118:2471–2481, 2008.

Zhang, X., F.Y. Che, I. Berezniuk, K. Sonmez, L. Toll, and L.D. Fricker. Peptidomics of Cpe mouse brain regions: implications for neuropeptide processing. J Neurochem 07:1596–613, 2008.

Abstracts and Presentations

Blanco-Centurion, C.A., P.J. Shiromani, and D. Gerashchenko. Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. Sleep 31(2), 2008.

Colrain, I.M., F.C. Baker, S. Turlington, M. Freeland, A. Wagstaff, M.A. Greco, M. McElroy, R. Krasnow, and G.E. Swan. The impact of smoking cessation on sleep. Associated Professional Sleep Societies Annual Meeting, Baltimore, MD, June 7–12, 2008.

Jiang, P., M. Striz, K. Shimomura, J.S. Takahashi, J.P. Wisor, and B.F. O’Hara. A mouse model for familial advanced sleep phase syndrome. Sleep 31:1103, 2008.

Pasumarthi, R.K., J.P. Wisor, D. Gerashchenko, and T.S. Kilduff. Differential expression of clock-related genes in the cerebral cortex of inbred mouse strains in response to sleep deprivation. Sleep 31:347, 2008.

Vazquez, J., S.C. Hall, M.A. Greco. Regional protein expression during spontaneous sleep-wakefulness. Abstract. Keystone Symposium, Biochemistry of Sleep (first Keystone meeting for sleep), Tahoe City, CA, March 2008.

Wisor, J.P. Adenosinergic and dopaminergic signaling as targets for wake-promoting therapeutics: insights from mouse genetic models. J Sleep Res 17:33, December 2008.

Zahr, N.M., D. Mayer, S. Vinco, J. Orduna, R. Luong, E.V. Sullivan, and A. Pfefferbaum. In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage. Neuropsycho­pharmacology, 2008.

Zahr, N.M., D. Mayer, S. Vinco, J. Orduna, E.V. Sullivan, and A. Pfefferbaum. Long-term alcohol exposure by vapor chamber alters MRS detectable metabolites in rat striatum. Alcoholism: Clin Exp Res 32(6):326A, June 2008.

Preclinical Development and Pharmaceutical Sciences

Publications

Bejugam, N.K., M. Sou, A.N. Uddin, S.G. Gayakwad, and M. J. D’Souza. Effect of chitosans and other excipients on the permeation of ketotifen, FITC-Dextran, and rhodamine 123 through caco-2 cells. J Bioactive and Compatible Polymers 23(2):187–202, 2008.

Bejugam, N.K., A.N. Uddin, S.G. Gayakwad, and M.J. D’Souza. Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer. J Microencapsulation 25(8):577–583, 2008.

Campbell, A., D. Holstege, R. Swezey, and D. Medina-Cleghorn. Detoxification of molinate sulfoxide: comparison of spontaneous and enzmatic glutathione conjugation using human and rat liver cytosol. J Toxicol Environ Health Pt. A 71:1338–1347, 2008.

Dieterich, C., A. Puey, S. Lyn, R. Swezey, A. Furimsky, D. Fairchild, J.C. Mirsalis, and H.H. Ng. Gene expression analysis reveals new possible mechanism of vancomycin-induced nephrotoxicity and identifies gene markers candidates. Toxicol Sci 107(1):258–69. Epub, Oct 16, 2008.

Dieterich, C., D. Iglehart, E. Riccio, J.C. Mirsalis, and H.H. Ng. Microarray evaluation of the Listeria monocytogenes infection and amoxicillin treatment in mice. Int J Toxicol 27:265–272, 2008.

Furimsky A.M., C.E. Green, L.E. Sharp, P. Catz, A.A. Adjei, T. Parman, I.M. Kapetanovic, R.M. Weinshilboum, and L. Iyer. Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1. Drug Metab Dispos 36(1):129–36, January 2008.

Liu, H., V. Manganiello, N.S. Waleh, and R.I. Clyman. Expression, activity and function of phosphodiesterases in the mature and immature ductus arteriosus. Pediatr Res 64:477–81, 2008.

Zabel, B. A., S. Nakae, L. Zúñiga, J.Y. Kim, T. Ohyama, C. Alt, J. Pan, H. Suto, D. Soler, S.J. Allen, T.M. Handel, C.H. Song, S.J. Galli, and E.C. Butcher. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exper Med 205(10):2207–2220, 2008.

Abstracts and Presentations

Bakke, J., A. Furimsky, R. Erickson, R. Swezey, L. Jong, I.M. Kapetanovic, J.A. Crowell, and C.E. Green. Pharmacokinetics and toxicity to rats of SR13668, a novel cancer chemopreventive agent. Society of Toxicology Annual Meeting, Seattle, WA, March 16–20, 2008.

Bejugam, N.K., S.K. Mutyam, H.J. Parish, and G.N. Shankar. Development of lipid-containing tablet formulations with adjustable release kinetics. AAPS Annual Meeting, Atlanta, GA, Nov 16–20, 2008.

Dieterich, D., A. Puey, S. Lin, R. Swezey, A. Furimsky, D. Fairchild, J.C. Mirsalis, and H.H. Ng. Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity. Abstract 453. Society of Toxicology Annual Meeting, Seattle, WA, March 16–20, 2008.

Erickson, R.I., E.B. Defensor, D.R. Middaugh, R. Garcia, J.C. Mirsalis, and K.L. Steinmetz. Low-dose exposure of neonatal rats to the antimalarial arteether results in brainstem pathology without obvious behavioral changes. The Toxicologist 102(1):1770, 2008.

Gemzik, B., and K. Steinmetz. Use of behavioral and non-routine neurological approaches in drug discovery toxicology. The Toxicologist 102(1):1361, 2008.

Horwith, G., M. Protopopova, L. Iyer, J. Mirsalis, Y. Li, and R. Swezey. Drug-drug interaction studies of SQ109 with first-line anti-TB drugs. 1st International Workshop on Clinical Pharmacology of TB Drugs, Toronto, Canada, May 15, 2008.

Messer, W., K. Steinmetz, T. Parman, P. Catz, C. Green, D. Ghosh, W. Hoss, and E. McGuire. Preclinical evaluation of CDD-0102, a selective M1 agonist with potential utility in Alzheimer’s disease. Alzheimer’s and Dementia 4(4):T505–T505, 2008.

Parman, T., D. Bunin K. Schweikart, J.E. Tomaszewski, K.K. Tanabe, and J. Mirsalis. Single and multiple dose toxicity studies of rRp450 (NSC-715818) in splenic reservoir mouse model. A4778. AACR Proceedings 49, 2008.

Rausch, L., P. Catz, S. LeValley, K. Steinmetz, C.E. Green, J. Tomaszewski, K. Schweikart, N. Zaveri, and J.C. Mirsalis. Biomarker levels in dogs after 28-day oral treatment with SR16157. Society of Toxicology Annual Meeting, Seattle, WA, March 16–20, 2008.

Rausch, L.L., P. Catz, S. LeValley, K. Steinmetz, C. Green, J. Tomaszewski, K. Schweikart, N. Zaveri, and J. Mirsalis. Biomarker levels in dogs after 28-day oral treatment with SR16157. The Toxicologist 102(1):392, 2008.

Steinmetz, K.L., L. Rausch, and B. MacQueen. Intravenous administration of gadolinium modified nanoparticles to Sprague-Dawley rats. Abstract 1033. Society of Toxicology, 2008.

Steinmetz, K.L. Preclinical development of neuropeptide therapeutics and diagnostics. Neuropeptides 42(1):114, 2008.

Radiation Biology and Therapy

Abstracts and Presentations

Blakely, E.A., A.C. Thompson, P. Chang, R.I. Schwarz, K.A. Bjornstad, C.J. Rosen, H.Y. Holman, D. Holman, and B. Parvin. Bystander signaling within and between cells. DOE Contractor’s Workshop, Washington, DC, January 21–23, 2008.

Blakely, E.A., K.A. Bjornstad, C.J. Rosen, D. Bunin, J.A. Moncaster, L.E. Goldstein, and P.Y. Chang. Early & late expression of particle radiation response markers. NASA Investigator’s Meeting, Philadelphia, PA, June 30–July 2, 2008.

Blakely, E.A., P.Y. Chang, K.A. Bjornstad, and C.J. Rosen. Particle radiation stress responses impact selective extracellular matrix gene expression during lens cell differentiation. NASA Human Research Program Investigator’s Workshop, League City, TX, February 4–6, 2008.

Blakely, E.A., R.I. Schwarz, K.A. Bjornstad, C.J. Rosen, D. Holman, P.Y. Chang, B. Parvin, and A.C. Thompson. DNA damage response and bystander effects of partially irradiated cells. 54th Annual Meeting for the Radiation Research Society, Boston, MA, September 21–25, 2008.

Chang, P.Y. Biomimetic actinide decorportation agents (presented in support of K. Raymond’s NCI RAID application). National Institutes of Health, Rockville, MD, September 12, 2008.

Chang, P.Y. (in collaboration with SRI’s Physical Sciences Division). Physical and biological dosimetry techniques and devices useful in initial triage after radiological and nuclear events. BARDA seminar, Washington, DC, September 4, 2008.

Chang, P.Y., J. Bakke, A. Wang, and D. Bunin. Impact of solar particle event on in vivo genotoxicity. NASA Investigator’s Meeting, Philadelphia, PA, June 30–July 2, 2008.

Chang, P.Y., J. Bakke, and D. Bunin. DNA damage and processing in CNS after particle radiation. NASA Human Research Program Investigator’s Workshop, League City, TX, February 4–6, 2008.

Chang, P.Y., J. Bakke, and D. Bunin. DNA damage and processing in brain tissues after HZE particle radiation. 54th Annual Meeting for the Radiation Research Society, Boston, MA, September 21–25, 2008.

Shankar, G.N., C.E. Green, K.W. Turteltaub, M. Sutton, N.K. Bejugam, and D.R. Cassatt. Oral Ca- and Zn-DTPA: effective treatment strategy for past radiation exposure. Radiation Research Society, 54th Annual Meeting, Boston, MA, September 21–24, 2008.

Other Publications, Abstracts, Presentations, and Patents

Publications

Basham, B., M. Sathe, J. Grein, T. McClanahan, A. D’Andrea, E. Lees, and A. Rascle. In vivo identification of novel STAT5 target genes. Nucleic Acids Res 36(11):3802–3818, 2008.

Karp, P.D., G. Sherlock, J.A. Gerlt, I. Sim, I. Paulsen, P.C. Babbitt, K. Laderoute, L. Hunter, P. Sternberg, J. Wooley, and P.E. Bourne. Changes to NIH grant system may backfire. Science 322(5905):1187–1188, 2008.

McCurnin, D., S. Seidner, L.Y. Chang, N.S. Waleh, M. Ikegami, J. Petershack, B. Yoder, L. Giavedoni, K. Albertine, M.-J. Dahl, Z. Wang, and R.I. Clyman. Ibuprofen-induced ductus arteriosus closure: physiological, histological and biochemical effects on the premature lung. Pediatrics 121:945–56, 2008.

Moos, W.H., J.A. Dykens, and N. Howell. 17 alpha-estradiol: A less-feminizing estrogen. Drug Dev Res 69(4):177–184, 2008.

Spack, E.G. Hybrids help out. Drug Discovery Dev 11(10):38–40, October 2008.

Uboldi, C., A. Döring, C. Alt, P. Estess, M. Siegelman, and B. Engelhardt. L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis. Eur J Immunol 38(8):2156–2167, 2008.

Waleh, N.S., J. Reese, H. Kajino, C. Roman, S. Seidner, D. McCurnin, and R.I. Clyman. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation. Am J Physiology. Epub ahead of print, 2008.

Abstracts and Presentations

Moos, W.H. A nonprofit research institute’s perspective on outsourcing R&D. bioLOGIC Europe 2008 (http://www.terrapinn.com/2008/bio_eur/), Geneva, Switzerland, September 18, 2008.

Moos, W.H. SRI Biosciences: “Idea to IND”™. BioJapan 2008 (http://expo.nikkeibp.co.jp/ biojapan/eng/), Yokohama, Japan, October 15, 2008.

Patents

Jong, L., and W.-R. Chao. Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents. U.S. Patent 7,429,610. September 30, 2008.

Zaveri, N., and W.-R. Chao. Novel Flavanols as Chemotherapeutic, Chemopreventive, and Antiangiogenic Agents. U.S. Patent 7,329,687. February 12, 2008.

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       Last Updated Dec 2, 2010