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PK/ADME Studies

Absorption, Distribution, Metabolism and Excretion (ADME) studies are a vital part of the comprehensive safety evaluation of a new chemical entity. SRI has more than 30 years of experience conducting in-vivo pharmacokinetic and metabolism studies for clients in the pharmaceutical, biotechnology, and medical products industries. We are also a leader in the use of human and animal tissues in vitro to predict interspecies differences.

SRI offers a multitude of ADME-related services:

• Screening assays for in vitro human drug metabolism
• Analytical method development and validation using LC/MS/MS techniques
• Bioavailability
• Drug interactions
• Unlabeled and radiolabeled compounds
• Animal studies characterizing
  • pharmacokinetics
  • distribution
  • excretion
  • metabolism

These studies can be conducted in any laboratory species. Routes of administration include oral, intravenous, dermal, intraperitoneal, inhalation, intrathecal, and infusion as well as other intended delivery methods for your compound.

Our experience and capabilities in both in-vivo and in-vitro work make SRI uniquely qualified to assist you throughout the process of product development.

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     Last Updated Jan 25, 2010