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Nanoparticle Drug Delivery

Liposomes and other nanotechnology-enabled formulations can improve drug solubility, reduce toxicity, protect drugs from degradation, and target drugs to specific sites in the body. These advantages are highly desired for many applications, including: cancer therapies, imaging agents, vaccines, nutraceuticals, and cosmetics.

SRI’s Nanoparticle Drug Delivery team offers custom liposome formulations to meet your discovery and research needs. SRI also provides comprehensive services in physical and biological characterization of all types of nanoparticles.

Formulation Capabilities

• Custom liposome formulation
–– Hydrophobic and hydrophilic small molecules
–– Peptides, proteins, nucleic acids
–– Antibody- and peptide-mediated targeting
–– Enzyme- and pH-dependent drug release

Comprehensive Services

• Analytical characterization of a broad range of nanoparticles
–– Liposomes, micelles, emulsions
–– Dendrimers, polymeric particles
–– Viruses, virus-like particles
–– Self-assembling biomolecules
–– Peptide and protein complexes

• Physical characterization
–– Particle size and size distribution
–– Particle morphology
–– Zeta potential

• Drug loading, release, and stability
–– Encapsulation efficiency
–– In vitro drug loading and release
–– Time-, temperature-, pH-dependent formulation stability
–– Liposome fusion and contents leakage
–– Custom 2D-LC-MS/MS assay development and validation

• In vitro bioactivity of nanoparticles
–– Cell binding and uptake
–– Optimization of targeting ligands
–– Hemolysis and complement activation
–– Plasma stability and protein binding
–– Cytotoxicity (necrosis and apoptosis)
–– Custom cell-based potency assays

• In vivo safety and efficacy
–– SRI’s preclinical development team offers comprehensive services for in vivo evaluation of your
nanoparticle drug formulation, including pharmacokinetics, toxicology, immunogenicity, and efficacy in disease models

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     Last Updated Apr 2, 2012