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In Vivo Cancer Drug Efficacy

From designing and performing animal studies to histopathology analysis and follow-up molecular biology and biochemistry experiments, our experienced staff works together with our clients to ensure that we provide the in vivo services they need. Our modern 12,000-square-foot animal facility includes suites dedicated to housing athymic mice, separate surgical suites, a complete pathology laboratory, state-of-the-art intravital and confocal microscopies for analysis, and an irradiator facility for evaluating the effect of test agents on the response of tumors to radiation therapy.

Scope of Services

We offer standard and unique animal model studies, including

Tumor Implants

• Human xenografts in nude athymic mice
• Syngeneic transplants in rats and mice
• Orthotopic and ectopic implantation
• Leukemia models (NOD/SCID)
• Lab Cat SystemŽ for rapid and precise tumor growth measurements

For a description, please download "Efficacy Evaluation of Cancer Drugs" (PDF)

Metastasis Models

• Spontaneous metastasis
  • Orthotopic and footpad implantation
• Intravenous injection

Angiogenesis Models

• Z-chamber
• Dorsal skin flap window chamber

For a description, please download "Evaluating Compounds Affecting Angiogenesis" (PDF)

Leukemia Models

Radiation Therapy Response

• X-ray and cesium sources
• Lung and GI toxicity
• Evaluation of radiation sensitizers and protectants

For a description, please download "Evaluating Drug Effects on Radiation Efficacy and Toxicity" (PDF)

Stem Cell Research

• Bone marrow repopulation assay
• Ischemia/injury-induced recruitment assays
• Custom models for stem cell assessment

Pathology Services. We offer extensive animal and human pathology expertise and an advanced analysis system to provide services in

• Basic histology
• Immunohistology
• Fluorescent immunohistology
• Cellular hypoxia measurements

Molecular Biology and Biochemistry. Animal tissues recovered at the end of a study can be used in follow-up experiments, including

• In vitro efficacy assessment
• FACS analysis
• Biochemical assays on treated tissue
• Differential gene expression
• RNA isolation
• ELISA, western blots on tissue lysates

Contact SRI Biosciences

       Last Updated Jan 25, 2010